Pituitary tumors contain a (CD31¯/CD45¯ purified) side population with 'tumor stem cell'-associated characteristics [set 2]

ABSTRACT: Pituitary adenomas cause significant endocrine and mass-related morbidity. Not much is known about mechanisms underlying pituitary tumor pathogenesis. We searched for a side population (SP) in pituitary tumor, representing cells with high efflux capacity and potentially enriching for cancer/tumor stem cells (CSC/TSC). Human pituitary adenomas contain a SP irrespective of hormonal phenotype. This adenoma SP, as well as the further purified SP (pSP) depleted from endothelial and immune cells, enriches for cells that express ‘tumor stemness’ markers and signaling pathways, including epithelial-mesenchymal transition (EMT)-linked factors. The adenomas were found to contain self-renewing sphere-forming cells, considered a property of TSC. The sphere-initiating cells were retrieved in the pSP. B

ORGANISM(S): Homo sapiens

SUBMITTER: Wouter Van Delm 

PROVIDER: E-GEOD-62870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress