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Late stage ovarian cancer gene expression profiles

ABSTRACT: Gene expression profiling on 63 stage III-IV papillary serous ovarian cancer samples resected during primary debulking at the University of Turin, Italy. Only the primary ovarian mass and no metastases were included in this analysis. The study focused on ovarian cancer chemokine expressions Only the primary ovarian mass and no metastases were included in this analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Hongzhe Li

PROVIDER: E-GEOD-62873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Project description:Tumor specimens were collected from women with ovarian tumors at primary surgery in a study covering most of Denmark called the MALOVA-study (MALignant OVArian cancer study). This multidisciplinary study on ovarian cancer covers epidemiology (life style factors), biochemistry, and molecular biology with the purpose of identifying risk factors and prognostic factors for EOC. The study has been approved by the Scientific Ethic Committees in the study area (KF01-384/95). Sample collection went on from 1994 to 1999, and the study is described in details in other articles(20;21;24;30). Histopathological classification of the ovarian tumors was based on the typing criteria of the WHO. Pathology reports and tissue were collected from the participating hospitals. One pathologist specialized in ovarian tumors, reviewed the tissue specimens without knowledge of the primary diagnoses. Subsequently, the reviewed diagnosis was compared to the original diagnosis and agreement on invasiveness was present in 98 % of the cases. The histopathological type was refined in 14% of the cases. FIGO stages were obtained from clinical records and were reviewed by two gynecologists, both specialized in OC. Reviewed data were used for further analysis. Furthermore all other relevant hospital files were collected, and data concerning, debulking status, CA-125 level prior to operation, amount and type of chemotherapy and cause of death (if dead) were registered. Patients were scored as ÂradicalÂ (optimally debulked) if no macroscopic residual tumor nodules were left, and as Ânon-radicalÂ (sub-optimally debulked) if macroscopic nodules were left. All fresh tumor samples included in this study were intended to be snap frozen within 20 minutes after the tumor was removed, but exact transportation time is not known. All samples have been stored at -80ÂºC. We selected samples from the largest and most common histological subtype, the serous ovarian cancers, all stages. The tumor sample material consisted of 70 stage III/IV tumors and 19 stage I/II tumors. Further patient information can be obtained from the submitters on request.