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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse multipotent adult progenitor cells (MAPCs), 2 different clones

ABSTRACT: We compare the transcriptome of two different clones of multipotent adult progenitor cells (MAPCs) using Affymetrix arrays. Experiment Overall Design: Three mRNA samples (biological replicates) per cell type taken at different passage number were compared. Two independently isolated MAPC clones were used.

ORGANISM(S): Mus musculus

SUBMITTER: Fernando Ulloa Montoya

PROVIDER: E-GEOD-6291 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells.

Serafini Marta M Dylla Scott J SJ Oki Masayuki M Heremans Yves Y Tolar Jakub J Jiang Yuehua Y Buckley Shannon M SM Pelacho Beatriz B Burns Terry C TC Frommer Sarah S Rossi Derrick J DJ Bryder David D Panoskaltsis-Mortari Angela A O'Shaughnessy Matthew J MJ Nelson-Holte Molly M Fine Gabriel C GC Weissman Irving L IL Blazar Bruce R BR Verfaillie Catherine M CM

The Journal of experimental medicine 20070116 1

For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been an elusive goal. Here, we demonstrate that multipotent adult progenitor cells (MAPCs), isolated from green fluorescent protein (GFP)-transgenic mice and expanded in vitro for >40-80 population doublings, are capable of multilineage hematopoietic engraftment of immunodeficient mice. Among MAPC-derived GFP+CD45.2+ cells in the bone marrow of engrafted mice, HSCs were present that could radioprotect and recon ...[more]

PMID: 17227908

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Transcription profiling of mouse multipotent adult progenitor cells

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