Human cells contain natural double-stranded RNAs with potential regulatory capacity

ABSTRACT: Although recent evidence suggests that overlapping sense/antisense transcription is a common feature in higher eukaryotes, the possibility that overlapping transcripts could interact to each other and bear a specific biological function has not been explored. Here we show that a plethora of sense/antisense transcript pairs are co-expressed from 8q24.21 within the same cell and acquire a stable double-stranded RNA conformation. Interestingly, these molecules display predominantly nuclear localization and establish specific interactions with nuclear components. A detailed characterization of a particular sense/antisense pair (ndsRNA-2a) revealed that this molecule displays differential localization throughout the cell cycle, interacts with RCC1 and RAN and through the latter with the mitotic

ORGANISM(S): Homo sapiens

SUBMITTER: Maximiliano Portal 

PROVIDER: E-GEOD-62930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress