C/EBP? and PPAR?-specific transcriptional programs in mature adipocytes in vivo

ABSTRACT: We took a systematic approach to determine the transcriptional programs that are specifically regulated by C/EBP? in mature white adipocytes of mice on chow diet or high fat diet. The hypothesis tested in the present study was that C/EBP?, as a lipogenic transcription factor, has unique direct targets compared to PPAR?. Our inducible adipocyte specific knockout system allows us to test the direct targets of C/EBP? and PPAR? in adipocytes by short-term C/EBP? or PPAR? elimination in mature adipocytes in vivo. Results indicate that although it has been shown that C/EBP? and PPAR? cross-regulate each other, they have distinct direct responsive targets. Moreover, there are very few C/EBP? specific targets in mice on a chow diet, most of the C/EBP? targets in mature adipocytes are genes modulat

ORGANISM(S): Mus musculus

SUBMITTER: Qiong Wang 

PROVIDER: E-GEOD-62937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress