Evaluating the effects of cardiac telomerase re-activation after myocardial infarction in adult mice

ABSTRACT: Coronary heart disease is a main cause of death in the developed world and treatment success remains modest with high mortality rates within one year after myocardial infarction (MI). Thus, new therapeutic targets and effective treatments are necessary. Short telomeres are risk factors for age-associated diseases including heart disease. Here, we address the potential of telomerase (Tert) activation in prevention of heart failure after MI in adult mice. We use adeno-associated viruses for cardiac-specific Tert expression in a mouse model of MI. We find that upon MI, hearts expressing Tert show attenuated cardiac dilation, improved ventricular function and smaller infarct scars concomitant with increased mouse survival by 17% compared to controls. Furthermore, Tert treatment results in elon

ORGANISM(S): Mus musculus

SUBMITTER: Christian Baer 

PROVIDER: E-GEOD-62973 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress