Interrogation of a Context-Specific Transcription Factor Network Identifies Novel Regulators of Pluripotency

ABSTRACT: The predominant view of pluripotency regulation proposes a stable ground state with coordinated expression of key transcription factors (TFs) that prohibit differentiation. Another perspective suggests a more complexly regulated state involving competition between multiple lineage-specifying TFs that define pluripotency. These contrasting views were developed from extensive analyses of TFs in pluripotent cells in vitro. An experimentally-validated, genome-wide repertoire of the regulatory interactions that control pluripotency within the in vivo cellular contexts is yet to be developed. To address this limitation, we assembled a TF interactome of adult human male germ cell tumors (GCTs) using the Algorithm for the Accurate Reconstruction of Cellular Pathways (ARACNe) to analyze gene expr

ORGANISM(S): Homo sapiens

SUBMITTER: Raju Chaganti 

PROVIDER: E-GEOD-62983 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress