Epigenetic effects of antidepressants to neuroprotective genes in neuronal cultured cells

ABSTRACT: Antidepressants are widely used for treatment of depression. Imipramine, a typical antidepressant, is recently known to have an effect to restore the expression of brain-derived neurotrophic factor gene, which is decreased in depressed patients, by increasing histone acetylation. However, it is largely unknown whether other antidepressants have similar epigenetic effects to change gene expression. To address this question, we examined the effect of five antidepressants (imipramine, citalopram, duloxetine, amitriptyline, mirtazapine) on expression of genes associated with mental and neurodegenetative disorders. We found that 48-hour treatment with imipramine, citalopram, amitriptyline, mirtazapine, but not duloxetine, caused a large number of differentially expressed genes in primary neocor

ORGANISM(S): Mus musculus

SUBMITTER: Kunio Miyake 

PROVIDER: E-GEOD-63005 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress