An integrated transcriptome and expressed variant analysis of sepsis survival and death

ABSTRACT: Background: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical characterizations fail to identify those at greatest risk of progression and mortality. Results: The Community Acquired Pneumonia and Sepsis Outcome Diagnostic study enrolled 1,152 subjects with suspected sepsis. We sequenced peripheral blood RNA of 129 representative subjects with systemic inflammatory response syndrome (SIRS) or sepsis (infection with SIRS), including 78 sepsis survivors and 28 sepsis nonsurvivors, who had previously undergone plasma proteomic and metabolomic profiling. The expression of 338 genes differed between subject

ORGANISM(S): Homo sapiens

SUBMITTER: Raymond Langley 

PROVIDER: E-GEOD-63042 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress