CX3CR1/Fractalkine receptor expression separates memory CD8+ T cells with distinct functional profiles (expression)

ABSTRACT: Memory T cells are important for protective immunity against infectious microorganisms. Such protection is achieved by cooperative action of memory T cell populations that differ in their tissue localization and functionality. We report on the identification of the fractalkine receptor CX3CR1 as marker for stratification of memory T cells with cytotoxic effector function from those with proliferative function in both, mice and man. Based on CX3CR1 and CD62L expression levels four distinct memory T cell populations can be distinguished based on their functional properties. Transcriptome and proteome profiling revealed that CX3CR1 expression was superior to CD62L to resolve memory T cell functionality and allowed determination of a core signature of memory T cells with cytotoxic effector fun

ORGANISM(S): Mus musculus

SUBMITTER: Joachim Schultze 

PROVIDER: E-GEOD-63118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress