The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium

ABSTRACT: In many developmental systems, morphogenesis is coupled with dramatic changes in spatiotemporal gene expression, often orchestrated by the coordinated action of transcription factors. Development of the social soil amoebae Dictyostelium discoideum proceeds through a sequence of morphological and transcriptional changes, but the role of transcription factors in development is not well understood. GtaC, a GATA-type zinc-finger transcription factor, is essential for Dictyostelium development. It decodes pulsatile extracellular cAMP signals during early development and mediates cell-type differentiation at later stages. Here, we studied the developmental regulatory roles of GtaC through the concerted analysis of temporal ChIP- and RNA-sequencing data from strains that carry different alleles o

ORGANISM(S): Dictyostelium discoideum

SUBMITTER: Gad Shaulsky 

PROVIDER: E-GEOD-63151 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress