Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation

ABSTRACT: Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: Time-pregnant mice were exposed to LG-SF or control sleep (LG-SC) conditions during the last 6 days of gestation. We performed large-scale DNA methylation analyses using MeDIP coupled to microarrays (MeDIP-chip) in VWAT of 24-week-old LG-SF and LG-SC offspring (n=8 mice/group). Univariate multiple-testing adjusted statistical analyses were applied to identify differentially methylated regions (DMRs) between the groups. DMRs were mapped to their corresponding genes, and tested for potential overl

ORGANISM(S): Mus musculus

SUBMITTER: Rene Cortese 

PROVIDER: E-GEOD-63208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress