Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells (3)

ABSTRACT: DNA methylation is thought to induce a transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators that do not recognize their binding sites when methylated, and the recruitment of transcriptional repressors that specifically bind methylated DNA. Methyl CpG Binding Domain proteins MeCP2, MBD1 and MBD2 belong to the latter category. However, the exact contribution of each protein in the DNA methylation dependent transcriptional repression occurring during development and diseases remains elusive. Here we present MBD2 ChIPseq data generated from the endogenous protein in an isogenic cellular model of human mammary oncogenic transformation. In immortalized or transformed cells, MBD2 was found in one fourth of methylated regions and associat

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Dante 

PROVIDER: E-GEOD-63235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress