Expression profiles of normal hematopoietic stem and progenitor cells and acute myeloid leukemia sub-populations

ABSTRACT: Acute Myeloid Leukemia AML is a cancer in which the process of normal cell hematopoietic differentiation is disrupted. Evidence exists that AML comprises a hierarchy with leukemic stem cells giving rise to more differentiated, but immature and functionally incompetent populations. The similarity of these AML subpopulations to normal stages of hematopoietic differentiation has not been dissected comprehensively at the transcriptional level. Here we introduce Normal Memory Analysis (NorMA), a data analysis method that extracts from omic data the remnants of the healthy normal-like phenotype. Applying NorMA to gene expression data from AML uncovered a wealth of information in the normal-like component of data: the normal hematopoietic memory of AML tumor cells. We found significant variation

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Gentles 

PROVIDER: E-GEOD-63270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress