Proteus mirabilis mrpJ microarrays

ABSTRACT: This series of microarrays compares gene expression by the bacterial pathogen Proteus mirabilis when the transcriptional regulator mrpJ is deleted or induced to levels found during experimental urinary tract infection. The enteric bacterium Proteus mirabilis is associated with a significant number of catheter-associated urinary tract infections. Strict regulation of the antagonistic processes of adhesion and motility, mediated by fimbriae and flagella, respectively, is essential for successful disease progression. Previously, the transcriptional regulator MrpJ, which is encoded by the mrp fimbrial operon, has been shown to repress both swimming and swarming motility. Here we show that MrpJ affects a wide array of cellular processes beyond adherence and motility. Microarray analysis found

ORGANISM(S): Proteus mirabilis HI4320

SUBMITTER: Melanie Pearson 

PROVIDER: E-GEOD-63321 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress