Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment [RNA-seq]

ABSTRACT: Macrophages are hematopoietic cells critical for innate immune defense, but also control organ homeostasis in a tissue-specific manner. Tissue-resident macrophages, therefore, provide a well-defined model to study the impact of ontogeny and microenvironment on chromatin state. Here, we profile the dynamics of four histone modifications across seven tissue-resident macrophage populations, as well as monocytes and neutrophils. We identify 12,743 macrophage-specific enhancers and establish that tissue-resident macrophages have distinct enhancer landscapes. Our work suggests that a combination of tissue and lineage-specific transcription factors form the regulatory networks controlling chromatin specification in tissue-resident macrophages. The environment has the capacity to alter the chromat

ORGANISM(S): Mus musculus

SUBMITTER: Ido Amit 

PROVIDER: E-GEOD-63340 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress