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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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DNA methylation profiles of brain samples from Down Syndrome subjects and controls.

ABSTRACT: Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 71 samples from multiple brain regions (cerebellum, temporal/occipital/frontal cortex). The goal was to evalute the effect of trisomy 21 on DNA methylation levels and epigenetic age. Explanation of characteristics variables in supplementary file Explanation_of_characteristic_variables2.docx Bisulphite converted DNA from the 71 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Trisomy 21 (Down syndrome status) was related to CpGs.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath

PROVIDER: E-GEOD-63347 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Accelerated epigenetic aging in Down syndrome.

Horvath Steve S Garagnani Paolo P Bacalini Maria Giulia MG Pirazzini Chiara C Salvioli Stefano S Gentilini Davide D Di Blasio Anna Maria AM Giuliani Cristina C Tung Spencer S Vinters Harry V HV Franceschi Claudio C

Aging cell 20150209 3

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7 ...[more]

PMID: 25678027

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