DNA methylation profiles of brain samples from Down Syndrome subjects and controls.

ABSTRACT: Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 71 samples from multiple brain regions (cerebellum, temporal/occipital/frontal cortex). The goal was to evalute the effect of trisomy 21 on DNA methylation levels and epigenetic age. Explanation of characteristics variables in supplementary file Explanation_of_characteristic_variables2.docx Bisulphite converted DNA from the 71 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Trisomy 21 (Down syndrome status) was related to CpGs.

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath 

PROVIDER: E-GEOD-63347 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress