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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profile of primary cortical neurons from necdin-null mouse embryo

ABSTRACT: Necdin, a pleiotropic protein expressed predominantly in postmitotic neurons of mammals, regulates neuronal development and survival by interacting with various regulatory proteins. To understand a novel function of necdin, we analyzed gene expression profile of primary cortical neurons prepared from necdin-null mice at embryonic day 14.5. Wild-type and necdin-null cortical cells were prepared from mice at embryonic day 14.5. These cells were incubated in Neurobasal medium supplemented with B27 and differentiated into neurons for 4 days (>97% MAP2-positive postmitotic neurons). Three mice per genotype were used for analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Koichi Hasegawa

PROVIDER: E-GEOD-63498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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