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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MiRNA profile of microglial cells under oxygen-glucose deprivation

ABSTRACT: Migroglia cells were exposed to oxygen-glucose deprivation (OGD) for 3 h. The miRNA was isolated and the expression profiles of OGD-activated cells were compared with the profiles of resting cells. Two samples were analysed. miRNAs that were differentially expressed (increased or decreased in expression by â¥1.5-fold) between theOGD-activated and resting cells were identified.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Peng Wang

PROVIDER: E-GEOD-63504 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4.

Zhang Li L Li Ya-Jian YJ Wu Xun-Yi XY Hong Zhen Z Wei Wen-Shi WS

Journal of neurochemistry 20150212 6

Cerebral hypoxia/ischemia rapidly induces inflammation in the brain, which is characterized by microglial activation and the release of inflammatory cytokines. We have previously demonstrated that miR-181c can directly regulate tumor necrosis factor (TNF)-α production post-transcriptionally. Here, we determined that hypoxia up-regulated TLR4 expression but down-regulated miR-181c expression in primary microglia. We also demonstrated that miR-181c suppresses TLR4 by directly binding its 3'-untran ...[more]

PMID: 25545945

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