A comprehensive analysis of blood host responses to Yersinia Pestis infection Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis

ABSTRACT: transcriptomic analyses showed there was a very rapid proliferation of Y. pestis in assault on African green monkeys. The bacterial loads were enumerated in the blood at delayed time points supporting earlier observations (Layton et al., 2011). Interpretation of transcriptomic changes reveals that the host defense has been essentially shattered, and the process of multi-organ failure was initiated one day after inhalation exposure. At 24 h post-exposure, the diseased animals were possibly at the middle of their survival curves. Hence, such molecular indicators could have critical therapeutic values, particularly when therapies fail to intervene at the earliest opportunity. In the early phase of pathogenesis, systematic reprogramming of both adaptive and innate immunity programs is media

ORGANISM(S): Chlorocebus aethiops

SUBMITTER: Rasha Hammamieh 

PROVIDER: E-GEOD-63560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress