Transcriptomic change of Legionella pneumophila in water.

ABSTRACT: Legionella pneumophila (Lp) is an opportunistic pathogen and its survival in water is critical for human infection. Therefore, identifying the genes of Lp that are required for survival in water may help devise strategies to prevent Legionella outbreaks. In this study, we exposed Lp in rich medium and in an artificial freshwater medium (Fraquil) for 2, 6 and 24 hours to uncover the global transcriptomic changes of Lp in water. The repression of major metabolic pathways, such as division, transcription and translation, suggests that Lp enters a dormant state in water. The induction of the flagellar associated genes (flg, fli and mot), enhance entry genes (enh) and some Icm/Dot effectors suggests that Lp may be waiting to establish intracellular replication in suitable host. Moreover, many g

ORGANISM(S): Legionella pneumophila subsp. pneumophila str. Philadelphia 1

SUBMITTER: Sebastien Faucher 

PROVIDER: E-GEOD-63622 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress