Global gene expression analysis of human fibroblasts from whole body

ABSTRACT: Fibroblasts are the principal stromal cells that exist in whole organs and play vital roles in many biological processes. Although the functional diversity of fibroblasts has been estimated, a comprehensive analysis of fibroblasts from the whole body has not been performed and their phenotypical diversity has not been sufficiently explored. The aim of this study was to elucidate the phenotypical diversity of human fibroblasts within the whole body. Global gene expression analysis of 63 human primary fibroblasts from 13 organs elucidated that fibroblasts from the gastrointestinal tract showed a remarkably distinct character compared to that seen in other organs. Furthermore, gastrointestinal fibroblasts were created by topologically diverse subgroups of fibroblasts depending on their organ

ORGANISM(S): Homo sapiens

SUBMITTER: Youichi Higuchi 

PROVIDER: E-GEOD-63626 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress