Host-virus transcriptome dynamics during infection of three cyanobacteria by a single phage reveals a unique regulatory program

ABSTRACT: Cyanobacteria are highly abundant in the oceans where they are constantly exposed to lytic viruses. Some viruses are restricted to a narrow host range while others infect a broad range of hosts. It is currently unknown whether broad-host range phages employ the same infection program, or regulate their program in a host-specific manner to accommodate for the different genetic makeup and defense systems of each host. Here we used a combination of microarray and RNA-seq analyses to investigate the interaction of three phylogentically distinct Synechococcus strains, WH7803, WH8102, and WH8109, with the broad-host range T4-like myovirus, Syn9, during infection. Strikingly, we found that the phage led a nearly identical expression program in the three hosts despite considerable differences in h

ORGANISM(S): Synechococcus sp. WH 8102

SUBMITTER: Miguel Hernández-Prieto 

PROVIDER: E-GEOD-63690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress