Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA

ABSTRACT: RNA sequencing of wild-type or Interferon Alpha receptor 1 Knockout MEF cells treated with DMSO or the Broad-spectrum Caspase Inhibitor Q-VD-OPh The mechanism by which cells undergo death determines whether dying cells trigger inflammatory responses or remain immunologically silent. Mitochondria play a central role in the induction of cell death, as well as in immune signaling pathways. Here, we identify of a mechanism by which mitochondria and downstream pro-apoptotic caspases regulate the activation of antiviral immunity. In the absence of active caspases, mitochondrial outer membrane permeabilization by Bax and Bak results in the expression of type I interferons (IFNs). This induction is mediated by mitochondrial DNA-dependent activation of the cGAS/STING pathway and results in the esta

ORGANISM(S): Mus musculus

SUBMITTER: Christian Harman 

PROVIDER: E-GEOD-63794 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress