Effect of embryo in vitro culture on mESC transcriptome.

ABSTRACT: Transcriptome analysis of mouse embryonic stem cell lines derived from embryos cultured in optimal and suboptimal conditions compared to cell lines derived from control embryos. The use of assisted reproductive technologies (ART) such as in vitro fertilization (IVF) has resulted in the birth of more than 5 million children. While children conceived by these technologies are generally healthy, there is conflicting evidence suggesting an increase in adult-onset complications like glucose intolerance and high blood pressure in IVF children. Animal models indicate similar potential risks. It remains unclear what molecular mechanisms may be operating during in vitro culture to predispose the embryo to these diseases. One of the limitations faced by investigators is the paucity of the material i

ORGANISM(S): Mus musculus

SUBMITTER: Rhodel Simbulan 

PROVIDER: E-GEOD-63821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress