AKT network of genes and impaired myocardial contractility during murine acute chagasic myocarditis

ABSTRACT: Rationale: Chagasic disease is associated with high morbidity in Latin America. Acute Chagasic myocarditis is consistently found in acute infections but little is known about its contribution to chronic cardiomyopathy. The aim of the study was to phenotypically characterize two strains of mice with differential Chagas infection susceptibility and correlate strain myocarditis phenotypes with heart tissue gene expression. Methods: C57BL/6J and Balb/c mice were injected intraperitoneally with 0 or 150-200 tissue-derived trypomastigotes (Tulahuen strain). Echocardiograms, brain natriuretic peptide and troponin were measured. Heart tissue was harvested for histopathological analysis and gene expression profiling on microarrays. Genes differently expressed between infected Balb/c and C57BL/6J we

ORGANISM(S): Mus musculus

SUBMITTER: Andrés Henao-Martínez 

PROVIDER: E-GEOD-63847 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress