Toxicogenomics analysis of placenta samples from mice exposed to different doses of BPA

ABSTRACT: Bisphenol A (BPA) is a widespread Endocrine Disrupter mainly used in food contact plastics. Several evidences support BPA adverse effects, especially on susceptible groups such as pregnant women. The present study considered placental development - relevant for pregnancy outcomes and fetal nutrition/programming - as a potential target of BPA. Pregnant CD-1 mice were administered per os with vehicle, 0.5 (BPA05) or 50 mg/kg (BPA50) body weight (bw)/die of BPA, from gestational day (GD) 1 to GD11. At GD12, BPA50 induced significant degeneration and necrosis of giant cells, increased vacuolization in the junctional zone in absence of glycogen accumulation and reduction of the spongiotrophoblast layer. BPA05 induced a significant nuclear accumulation of M-NM-2-catenin in trophoblasts of the la

ORGANISM(S): Mus musculus

SUBMITTER: Sabrina Tait 

PROVIDER: E-GEOD-63852 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress