Gene Networks Specific for Innate Immunity Define Post-traumatic Stress Disorder [Affymetrix]

ABSTRACT: The molecular factors involved in the development of Post-traumatic Stress Disorder (PTSD) remain poorly understood. Previous transcriptomic studies investigating the mechanisms of PTSD apply targeted approaches to identify individual genes under a cross-sectional framework lack a holistic view of the behaviours and properties of these genes at the system-level. Here we sought to apply an unsupervised gene-network-based approach to a prospective experimental design using whole-transcriptome RNA-Seq gene expression from peripheral blood leukocytes of U.S. Marines (N=188), obtained both pre- and post-deployment to conflict zones. We identified discrete groups of co-regulated genes (i.e., co-expression modules) and tested them for association to PTSD. We identified one module at both pre- and

ORGANISM(S): Homo sapiens

SUBMITTER: Caroline Nievergelt 

PROVIDER: E-GEOD-63878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress