Gene expression profiling in ovarian cancer

ABSTRACT: The introduction of microarray techniques to cancer research brought great expectations for finding biomarkers that would improve patients’ treatment; however, the results of such studies are poorly reproducible and critical analyses of these methods are rare. In this study, we examined global gene expression in 97 ovarian cancer samples. Also, validation of results by quantitative RT-PCR was performed on 30 additional ovarian cancer samples. We carried out a number of systematic analyses in relation to several defined clinicopathological features. The main goal of our study was to delineate the molecular background of ovarian cancer chemoresistance and find biomarkers suitable for prediction of patients’ prognosis. We found that histological tumor type was the major source of variability

ORGANISM(S): Homo sapiens

SUBMITTER: Katarzyna Lisowska 

PROVIDER: E-GEOD-63885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress