Increased CD226 Expression on CD8+ T cells in Patients with Systemic Sclerosis

ABSTRACT: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular damage, and fibrosis of the skin and internal organs. Because activated and oligoclonally expanded CD8+ T cells can be detected in peripheral blood and lung of SSc patients, effector memory CD8+ T cells may play a critical role for organ involvement in SSc; however, the pathogenic functions of effector memory CD8+ T cells remain incompletely understood. Here we performed DNA microarray analysis of the sort-purified effector memory CD8+ T cells from SSc patients and healthy controls, and showed that the expression of genes related to immune response and cell adhesion, including CD226 (also known as DNAX accessory molecule-1, DNAM-1), was significantly altered. Moreover, detailed analysis of CD226 revealed that CD226

ORGANISM(S): Homo sapiens

SUBMITTER: Masahiro Ayano 

PROVIDER: E-GEOD-63903 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress