Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Francesco Villa
PROVIDER: E-GEOD-63912 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Villa Francesco F Carrizzo Albino A Spinelli Chiara C CC Ferrario Anna A Malovini Alberto A Maciąg Anna A Damato Antonio A Auricchio Alberto A Spinetti Gaia G Sangalli Elena E Dang Zexu Z Madonna Michele M Ambrosio Mariateresa M Sitia Leopoldo L Bigini Paolo P Calì Gaetano G Schreiber Stefan S Perls Thomas T Fucile Sergio S Mulas Francesca F Nebel Almut A Bellazzi Riccardo R Madeddu Paolo P Vecchione Carmine C Puca Annibale A AA
Circulation research 20150601 4
<h4>Rationale</h4>Long living individuals show delay of aging, which is characterized by the progressive loss of cardiovascular homeostasis, along with reduced endothelial nitric oxide synthase activity, endothelial dysfunction, and impairment of tissue repair after ischemic injury.<h4>Objective</h4>Exploit genetic analysis of long living individuals to reveal master molecular regulators of physiological aging and new targets for treatment of cardiovascular disease.<h4>Methods and results</h4>We ...[more]