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Genetic analysis reveals a longevity associated protein modulating endothelial function and angiogenesis

ABSTRACT: Transcriptome analysis in HEK293T transfected with plasmid carrying different isoforms of BPIFB4 gene. This gene was previously associated with exceptional longevity in a GWAS study performed on three different populations. Results indicate an up-regulation of stress response genes and proteostasis genes in HEK293T transfected with plasmid carrying the longevity-associated variant (LAV) of BPIFB4. Total RNA obtained from HEK293T over-expressing wild-type or mutated form of BPIFB4.

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Villa 

PROVIDER: E-GEOD-63912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Rationale</h4>Long living individuals show delay of aging, which is characterized by the progressive loss of cardiovascular homeostasis, along with reduced endothelial nitric oxide synthase activity, endothelial dysfunction, and impairment of tissue repair after ischemic injury.<h4>Objective</h4>Exploit genetic analysis of long living individuals to reveal master molecular regulators of physiological aging and new targets for treatment of cardiovascular disease.<h4>Methods and results</h4>We  ...[more]

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