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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of wildtype and Csnk2b-deficient Foxp3+ regulatory T cells transcriptomes

ABSTRACT: The goal of this study was to compare the transcriptional changes evoked by Csnk2b-deficiency in Foxp3+ regulatory T cells Messenger RNA profiles of CD4+Foxp3+ regulatory T cells isolated from 8 week old wild type (WT) and Csnk2b-deficient mice were generated by deep sequencing in duplicate, using Illumina MiSeq

ORGANISM(S): Mus musculus

SUBMITTER: Tobias Bopp

PROVIDER: E-GEOD-63961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo.

Ulges Alexander A Klein Matthias M Reuter Sebastian S Gerlitzki Bastian B Hoffmann Markus M Grebe Nadine N Staudt Valérie V Stergiou Natascha N Bohn Toszka T Brühl Till-Julius TJ Muth Sabine S Yurugi Hajime H Rajalingam Krishnaraj K Bellinghausen Iris I Tuettenberg Andrea A Hahn Susanne S Reißig Sonja S Haben Irma I Zipp Frauke F Waisman Ari A Probst Hans-Christian HC Beilhack Andreas A Buchou Thierry T Filhol-Cochet Odile O Boldyreff Brigitte B Breloer Minka M Jonuleit Helmut H Schild Hansjörg H Schmitt Edgar E Bopp Tobias T

Nature immunology 20150119 3

The quality of the adaptive immune response depends on the differentiation of distinct CD4(+) helper T cell subsets, and the magnitude of an immune response is controlled by CD4(+)Foxp3(+) regulatory T cells (Treg cells). However, how a tissue- and cell type-specific suppressor program of Treg cells is mechanistically orchestrated has remained largely unexplored. Through the use of Treg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated ...[more]

PMID: 25599562

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