Comparison of the Streptococcus pneumoniae D39 grown in AM17 compared to D39 wild-type grown in M17

ABSTRACT: In this study, we have explored the impact of ascorbic acid on the transcriptome of Streptococcus pneumoniae D39. The expression of several genes and operons, including the ula operon (which has been previously shown to be involved in ascorbic acid utilization), the AdcR regulon (which has been previously shown to be involved in zinc transport and virulence) and a PTS operon (which we denote here as ula2 operon) were altered in the presence of ascorbic acid. The ula2 operon consists of five genes, including the transcriptional activator ulaR2. Our M-NM-2-galactosidase assay data and transcriptome comparison of the ulaR2 mutant with the wild-type demonstrated that the transcriptional activator UlaR2 in the presence of ascorbic acid activates the expression of the ula2 operon. We further pre

ORGANISM(S): Streptococcus pneumoniae D39

SUBMITTER: Sulman Shafeeq 

PROVIDER: E-GEOD-64105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress