Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

ABSTRACT: Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-specific ‘oncogene’ that has a critical role in the pathogenesis of melanoma. MITF promotes melanoma cell proliferation, whereas sustained supression of MITF expression leads to senescence. By combining chromatin immunoprecipitation coupled to high throughput sequencing (ChIP-seq) and RNA sequen- cing analyses, we show that MITF directly regulates a set of genes required for DNA replication, repair and mitosis. Our results reveal how loss of MITF regulates mitotic fidelity, and through defective repl

ORGANISM(S): Homo sapiens

SUBMITTER: Patrick Laurette 

PROVIDER: E-GEOD-64137 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress