Dataset Information
Transcription profiling of murine db/db diabetic kidney to identify adipose differentiation-related protein and regulators of lipid homeostasis.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): non-diabetic
SUBMITTER: Michael Simonson
PROVIDER: E-GEOD-642 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney.
American journal of physiology. Renal physiology 20040113 5
We investigated the molecular basis of progressive diabetic renal injury in db/db mice by profiling kidney gene expression. Using high-density microarrays, we identified 482 RNA transcripts differentially expressed in 8-wk db/db vs. nondiabetic db/m kidneys, a time characterized by hyperglycemia but by little renal histopathology. By 16 wk significant mesangial expansion had developed. Sixteen-week db/db kidneys differentially expressed 639 RNA transcripts. Diabetic kidneys specifically expresse ...[more]
