Molecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA CD4)

ABSTRACT: Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separately, of CD4+ T lymphocytes isolated from CAMR patients compared to kidney transplant recipients with normal graft function and histology. In total peripheral lympho-monocytes, forty-five genes resulted differentially expressed between the two groups, most of them were up-regulated in CAMR and were involved in type I interferon signaling. In addition, in the same set of patients, 16 microRNAs resulted down-regulated in CAMR subjects compared to controls: 4 were predicted modulators of 6 mRNAs iden

ORGANISM(S): Homo sapiens

SUBMITTER: Paola Pontrelli 

PROVIDER: E-GEOD-64261 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress