Normal counterpart in the identification of a molecular signature for leukemic promyelocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Enrico Tagliafico
PROVIDER: E-GEOD-64282 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: Focus on DNA repair genes.
Casorelli I I Tenedini E E Tagliafico E E Blasi M F MF Giuliani A A Crescenzi M M Pelosi E E Testa U U Peschle C C Mele L L Diverio D D Breccia M M Lo-Coco F F Ferrari S S Bignami M M
Leukemia 20060921 11
Acute promyelocytic leukemia (APL) is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. Gene expression profiles of APL cells obtained from 16 patients were compared to eight samples of CD34+-derived normal promyelocytes. Malignant promyelocytes showed widespread changes in transcription in comparison to their normal counterpart and 1020 differentially expressed genes were identified. Discriminating genes include transcriptional regulators (FOS, JUN and HOX genes ...[more]
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