Dataset Information
Transcription profiling of rat whole brain samples from animals with repeated exposure to the anaesthetic isoflurane or halothane
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Roderic Eckenhoff
PROVIDER: E-GEOD-6433 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Rat brain DNA transcript profile of halothane and isoflurane exposure.
Pharmacogenetics and genomics 20060301 3
Inhaled anesthetics produce many effects and bind to a large number of brain proteins, but it is not yet clear if this is accompanied by widespread changes in gene expression of the biological targets. Such changes in expression might implicate functionally important targets from the large pool of binding targets. Both rats and isolated primary cortical neurons were exposed to anesthetics and DNA oligonucleotide microarrays were used to detect and quantify transcriptional changes in neural tissu ...[more]
