Transcriptional Reversion of Cardiac Myocyte Fate During Mammalian Cardiac Regeneration.

ABSTRACT: Rationale: Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level. Objective: The objectives of our study were to determine if myocytes revert the transcriptional phenotype to a less differentiated state during regeneration and to systematically interrogate the transcriptional data to identify and validate potential regulators of this process. Methods and Results: We derived a core transcriptional signature of injury-induced cardiac myocyte regeneration in mouse by comparing global transcriptional programs in a dynamic model of in vitro and in vivo cardiac myocyte differentiation

ORGANISM(S): Mus musculus

SUBMITTER: Laurie Boyer 

PROVIDER: E-GEOD-64403 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress