Differential gene expression in heart tubes of hand[173] null mutants vs. w[1118]

ABSTRACT: Hand proteins belong to the highly conserved family of basic Helix-Loop-Helix transcription factors and are critical for distinct developmental processes, including cardiogenesis and neurogenesis in vertebrates. In Drosophila melanogaster a single orthologous hand gene is expressed with absence of the respective protein causing semilethality during early larval instars. Surviving adult animals suffer from shortened lifespan associated with a disorganized myofibrillar structure being apparent in the dorsal vessel, the wing hearts and in midgut tissue. Based on these data, the major biological significance of Hand seems to be related to muscle development, maintenance or function; however, up to now the physiological basis for Hand functionality remained elusive. Thus, the identification of

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Julia Hoffmann 

PROVIDER: E-GEOD-64429 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress