Sex hormones establish a reserve pool of adult muscle stem cells at puberty

ABSTRACT: Quiescent satellite cells, also known as adult muscle stem cells, possess a remarkable ability to regenerate skeletal muscle upon injury throughout life. Although they mainly originate from multipotent stem/progenitors of the somite, the mechanism underlying the establishment of quiescent satellite cell populations is unknown. Here, we show that sex hormones induce Mind bomb-1 (Mib1) expression in myofibers at puberty, which activates Notch signaling in cycling juvenile satellite cells and causes them to be converted into quiescent adult satellite cells. Myofibers lacking Mib1 failed to send Notch signals to juvenile satellite cells, leading to impaired cell cycle exit and depletion. Genetic and inhibitor studies revealed that the hypothalamic-pituitary-gonadal axis drives Mib1 expression

ORGANISM(S): Mus musculus

SUBMITTER: Daekwan Seo 

PROVIDER: E-GEOD-64454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress