Enhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: MICHAEL ROSENFELD
PROVIDER: E-GEOD-64516 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.
Zhang Feng F Tanasa Bogdan B Merkurjev Daria D Lin Chijen C Song Xiaoyuan X Li Wenbo W Tan Yuliang Y Liu Zhijie Z Zhang Jie J Ohgi Kenneth A KA Krones Anna A Skowronska-Krawczyk Dorota D Rosenfeld Michael G MG
Proceedings of the National Academy of Sciences of the United States of America 20150120 5
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell-type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and repression events remain incompletely understood. Here we report the required actions of LIM domain-binding protein 1 (LDB1)/cofactor of LIM homeodomain protein 2/nuclear LIM interactor, interacting wit ...[more]
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