Estrogen Receptor Beta Impacts Hormone-Induced Alternative mRNA Splicing in Breast Cancer Cells

ABSTRACT: Estrogens play an important role in breast cancer (BC) development and progression, where the two isoforms of the estrogen receptor (ER? and ER?) are generally co-expressed and mediate the effects of these hormones in cancer cells. ER? has been suggested to exert an antagonist role toward the oncogenic activities of ER?, and for this reason it is considered an oncosuppressor. As clinical evidence regarding a prognostic role for this receptor subtype in hormone-responsive BC is still limited and conflicting, more knowledge is required on the biological functions of ER? in cancer cells. We described previously the ER? and ER? interactomes of BC cells, identifying specific and distinct patterns of protein interactions for the two receptors. In particular, we identified factors involved in mRN

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Rinaldi 

PROVIDER: E-GEOD-64590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress