Transcription profiling of human acne lesion vs. normal skin from acne and non acne patients

ABSTRACT: The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. In an attempt to understand the specific genes involved in inflammatory acne, we performed gene expression profiling in acne patients. Skin biopsies were obtained from an inflammatory papule and from normal skin in six patients with acne. Biopsies were also taken from normal skin of six subjects without acne. Gene array expression profiling was conducted using Affymetrix HG-U133A 2.0 arrays comparing lesional to nonlesional skin in acne patients and comparing nonlesional skin from acne patients to skin from normal subjects. Within the acne patients, 211 genes are upregulated in lesional

ORGANISM(S): Homo sapiens

SUBMITTER: Wei Zhao 

PROVIDER: E-GEOD-6475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress