Transcription profiling of mouse hippocampus after chronic fluoxetine treatment

ABSTRACT: Both the mechanism of action and the factors determining the behavioral response to antidepressants are unknown. It has been shown that antidepressant treatment promotes the proliferation and survival of hippocampal neurons via enhanced serotonergic signaling, but it is still unclear whether hippocampal neurogenesis is responsible for the behavioral response to antidepressants. Furthermore, a large subpopulation of patients fails to respond to antidepressant treatment due to presumed underlying genetic factors. In the present study, we have used the phenotypic and genotypic variability of inbred mouse strains to show that there is a genetic component to both the behavioral and neurogenic effects of chronic fluoxetine treatment, and that this antidepressant induces an increase in hippocampa

ORGANISM(S): Mus musculus

SUBMITTER: Mathew Pletcher 

PROVIDER: E-GEOD-6476 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress