Transcription profiling of mouse mECK36: a cell and animal model of virally induced Kaposis sarcoma

ABSTRACT: Transfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial lineage cells generated a cell (mECK36) that induced KS-like tumors in mice. mECK36 formed KSHV-harboring vascularized spindle-cell sarcomas that were LANA+ and displayed a KSHV and host transcriptomes reminiscent of KS tumors. Experiment Overall Design: There are three biological replicates per sample. Tumors (mKS) were compared the the human KS signature. mECK36 and mEC-V were compared to putative BM lineage cells.

ORGANISM(S): Mus musculus

SUBMITTER: Enrique Mesri 

PROVIDER: E-GEOD-6482 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress