Transcription profiling of mouse olfactory epithelium frpm Harlequin mutants compared to littermate controls

ABSTRACT: Microarray analysis of gene expression in the olfactory epithelium of Harlequin mouse as a model of oxidative-stress induced neurodegeneration of olfactory sensory neurons Experiment Overall Design: Olfactory epithelium from Harlequin mutant mice and littermate control mice was microdissected for RNA extraction and hybridization on Affymetrix microarrays. We compared levels of gene expression in 6-month old mice to begin to identify mechanisms of oxidative-stress induced neurodegeneration and to correlate the cellular changes that we observed in the olfactory epithelium by using histology and immunohistochemistry with gene expression changes.

ORGANISM(S): Mus musculus

SUBMITTER: Marilyn Getchell 

PROVIDER: E-GEOD-6485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress