Rosette-forming glioneuronal tumour arising in the spinal cord: a case report and molecular profiling

ABSTRACT: Rosette-forming glioneuronal tumour (RGNT) of the IV ventricle is a very recent entity, recognized in the latest WHO classification of Central Nervous System Tumors. It is composed by two distinct features: a glial component, with typical characteristics of pilocytic astrocytoma, and a component forming neurocytic rosettes, with eosinophilic regions positive for synaptofisin and/or perivascular rosettes. Herein, we describe a 33-year-old man with RGNT arising in a peculiar location, namely the spinal cord. We further performed an extensive immunohistochemistry and molecular analysis, using array-CGH (aCGH), whole exome and cancer-related hotspot sequencing, in order to better understand its underlying biology. The histology revealed a WHO grade I RGNT typically found in the fourth-ventricl

ORGANISM(S): Homo sapiens

SUBMITTER: Rui Reis 

PROVIDER: E-GEOD-64891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress