Genome-wide methylation analysis and gene expression profiling identifies genes silenced in non-seminoma cell lines [methylation]

ABSTRACT: Germ cell tumours (GCTs) are a complex group of malignancies. They are unique in developing from a pluripotent progenitor cell. The initial lesion is believed to be the relatively benign precursor lesion (ICGNU), from which either highly chemosensitive seminomas or the more aggressive non-seminomas develop. Previous analyses of selected genes have suggested that non-seminomas exhibit much higher levels of DNA methylation than seminomas. However, the genomic targets that are methylated, the extent to which this results in gene silencing and the identity of the silenced genes most likely to play a role in the tumours’ biology have not yet been established. Here genome-wide methylation and expression analysis of GCT cell lines was combined with gene expression data. This demonstrated that

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Scotting 

PROVIDER: E-GEOD-65027 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress