Transcription profiling of skin from vitiligo patients and healthy volunteers reveals the WNT pathway as a target for re-pigmenting vitiligo lesions

ABSTRACT: Vitiligo is an acquired depigmentation of the skin inducing a marked alteration of the quality of life of affected individuals. Halting the disease progression and repigmenting the lesional skin represent the two faces of the therapeutic challenge in vitiligo. So far, none of them has been successfully addressed. Oxidative stress and immune system in genetically predisposed individuals participate to the complex pathophysiology of vitiligo. We performed a transcriptome and proteomic analysis on lesional, perilesional and non-depigmented skin of vitiligo patients compared to matched skin controls of healthy subjects. Our results show that the WNT pathway, implicated in melanocytes differentiation, was found to be altered in vitiligo skin. We demonstrated that the oxidative stress decreases

ORGANISM(S): Homo sapiens

SUBMITTER: Florence Joly 

PROVIDER: E-GEOD-65127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress